Level of serum leptin in newly diagnosed type 1 diabetic patients and the effect of short-term insulin therapy on it
- VernacularTitle:新诊断1型糖尿病患者血清瘦素质量浓度及短期胰岛素治疗对其影响
- Author:
Li CONG
;
Qiang LI
;
Jinchao ZHANG
- Publication Type:Journal Article
- Keywords:
Newly diagnosed Type 1 diabetes Leptin Insulin
- From:
Chinese Journal of Practical Internal Medicine
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of leptin levels in newly diagnosed type 1 diabetic patients and the effect of insulin therapy on serum leptin levels,so as to investigate the relationship between insulin and leptin.Methods Twenty-nine type 1 diabetic patients were enrolled from out-patient clinic and ward of our hospital.Twenty healthy people in our hospital were selected as normal controls.All blood samples were obtained after an overnight fasting for 14 hours.Fasting serum levels of glucose,hemoglobinA 1c(HbA 1c),triglycerides,cholesterol,insulin,C-peptide and leptin were analyzed in all subjects.The type 1 diabetic patients received insulin injection subcutaneously,and levels of glucose,insulin,C-peptide and leptin were measured 2 weeks later.Results In newly diagnosed type 1 diabetic patients,leptin levels were lower than those in normal controls (P0.05).It was found by correlation analysis that in control group,serum leptin levels were correlated with sex,BMI and serum insulin levels,while in newly diagnosed type 1 diabetic group,serum leptin levels were related to sex and serum insulin levels.Conclusion Serum leptin levels of patients with newly diagnosed type 1 diabetes are lower than those in control group.It is likely that short-term insulin injection subcutaneously can not affect serum leptin levels.
