Study on antiasthmatic activity of seratrodast derivative connected with NO donors
- VernacularTitle:一氧化氮藕联的塞曲司特衍生物抗哮喘活性的研究
- Author:
Sugan QIU
;
Hui JI
;
Yihua ZHANG
;
Zhiguo ZHANG
- Publication Type:Journal Article
- Keywords:
seratrodast;
furoxan derivatives;
N-Hydroxyguanidine;
antiasthma;
NO in vitro releasement
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To estimate the antiasthmatic activity of new compounds: SDF-1, SDG-1 and SDG-3. F-1 is a furoxan derivative, G-1 and G-3 are hydroxylguanidine derivatives, SDF-1 is a novel seratrodast derivative connected with F-1, SDG-1 a seratrodast derivative connected with G-1, and SDG-3 a novel seratrodast derivative connected with G-3. METHODS: Firstly, the in vivo antiasthmatic activity was estimated in asthmatic guinea pigs induced by acetylcholine and histamine. Secondly, the in vitro NO releasement of these compounds was determined following the procedures of Griess. Finally, tracheal smooth muscle relexant potency of these compounds was evaluated on trachea of guinea pigs. RESULTS: The in vivo antiasthmatic activity of SDF-1 was more potent than seratrodast (P
