p38MAPK: novel therapeutic target to slow the progression of Alzheimers disease
- VernacularTitle:p38MAPK——控制阿尔采末病进程的新靶点
- Author:
Shu WANG
;
Lan SUN
;
Guanhua DU
- Publication Type:Journal Article
- Keywords:
Alzheimers disease;
MAPK;
p38MAPK;
neurodegeneration;
tau;
neurofibrillary tangles
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimers disease (AD) is a neurodegenerative disorder severely affecting the aged population. Its pathological hallmarks include amyloid plaques, neurofibrillary tangles, loss of synapes and neurons as well as brain inflammation. This review focuses on multiple roles of p38MAPK, one of the members of mitogen-activated protein kinases(MAPK) family, in the pathogenesis and progression of AD. The review discusses the evidences of p38 activation in AD models, its connection with each pathological mark of AD and the interaction between p38 and significant pathophysiological process, such as inflammation, neuronal apoptosis and hyperphosphorylation of tau. Moreover, a discussion is also made to address the basis of p38 as the target for therapeutic intervention in AD. All in all, p38 is considered to be a new promising target for drugs to control the progression of AD.
