Protective effects of ulinastatin on renal function in rabbits with traumatic hemorrhagic shock
- VernacularTitle:乌司他丁对创伤失血性休克兔肾功能的保护作用
- Author:
Tingting CHEN
;
Gang WANG
;
Changqin GAO
- Publication Type:Journal Article
- Keywords:
ulinastatin;
shock, hemorrhagic;
kidney failure;
peroxidase
- From:Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the protective effects of ulinastatin on renal function in rabbits with traumatic hemorrhagic shock. Methods Thirty rabbits were randomly allocated to three groups: control group, traumatic hemorrhagic shock group and ulinastatin treatment group. Blood was sampled at two time points: pre-shock and 4h after blood volume replenishment, and the plasma levels of NE, BUN and Cr were measured. 4h after blood volume replenishment, the rabbits were sacrificed, and the activity of MPO in renal tissue and urine NAG were measured. Results In all the three groups, the plasma concentrations of BUN and Cr were somewhat elevated but showed no statistical significance in comparison with each other. The activity of NE in blood, MPO in renal tissue and NAG in urine were increased significantly in the traumatic hemorrhagic shock group compared with those of ulinastatin-treated group (P
