The protective effects of total flavones metasequosia on experimental myocardial infarction in anaesthetized dogs
- VernacularTitle:水杉总黄酮对麻醉犬实验性心肌梗死的保护作用
- Author:
Fang WANG
;
Enxin YU
;
Weiwan LIU
;
Zhiben TU
- Publication Type:Journal Article
- Keywords:
total flavones of metasequosia glyptostroboides;
coronary circulation;
myocardial oxygen consumption;
myocardial metabolism;
myocardial infarction
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the protective effects of total flavones metasequosia(TFM) on experimental acute myocardial infarction (AMI) in anaesthetized dogs. METHODS The parameters of coronary circulation and myocardial oxygen consumption, the degree and range of myocardial ischemia, myocardial infarct size, the activity of serum CK,LDH and the content of FFA were determined by using the AMI model of ligature of LAD in the anaesthetized open-chest dogs. RESULTS In dogs treated with TFM(in a dosage of 25, 100 mg?kg -1 , id), the myocardial oxygen consumption, degree and range of myocardial ischemia, myocardial infarct size, the activity of serum CK,LDH and the content of FFA were decreased. At the same time, myocardial blood flow was increased and coronary vascular resistance decreased significantly. CONCLUSION TFM possesses a protective effect on myocardial ischemia by modifying dysfunction of FFA, decreasing myocardial oxygen consumption and increasing myocardial blood supply.-
