Effect of salvia miltiorrhiza on the change of pulmanory pathology and expression of nuclear factor-kappa B in mice pulmonary fibrosis
- VernacularTitle:丹参对实验性肺纤维化小鼠病理变化和核因子-?B表达的影响
- Author:
Jing DONG
;
Weina MIAO
;
Guilin LUO
;
Shaotang LIU
- Publication Type:Journal Article
- Keywords:
salvia miltiorrhiza;
bleomycin;
pulmonary fibrosis;
NF -?B
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study effect of Salvia miltiorrhiza on the change of pulmanory pathology and expression of nuclear factor-kappa B in mice pulmonary fibrosis. METHODS Mice models were reproduced by injecting bleomycin to the trachea. Then the mice were treated with Salvia multiorrhiza. Observed Salvia miltiorrhiza effect on the mice models included pulmonary index, pulmonary pat hology and expression of NF-?B in pulmonary tissue by immunohistochemical technique. RESULTS Salvia miltiorrhiza depressed pulmonary index, reduced pulmonary pathological damage. At the same time, we also observed that it suppressed the abnormaly increased expression of NF-?B in pulmonary tissue of pulmonary fibrosis mice. CONCLUSION Salvia miltiorrhiza has good effect on reliefing pulmonary fibrosis reproduced by bleomycin.
