HEPATOPROTECTIVE ACTIVITY OF LOW MOLECULAR FUCOIDAN OLIGOSACCHARIDES FROM LAMINARIA JAPONICA IN MICE WITH LIVER INJURY
- VernacularTitle:海带岩藻聚糖硫酸酯低聚糖对小鼠肝损伤的保护作用
- Author:
Xue ZHAO
;
Changhu XUE
;
Jingfeng WANG
;
Zhaojie LI
;
Hongtao QI
- Publication Type:Journal Article
- Keywords:
Low molecular fucoidan oligosaccharides;
liver damage
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the antioxidative and hepatoprotective activities of low molecular fucoidan oligosaccharides(LMFO) from Laminaria japonica in mice.Methods: Mice were pretreated with LMFO(50?100?150 mg/kg ig respectively, 10 days),and then 0.2 % CCl 4 10 ml/kg ig and D-GalN(600 mg/kg)+LPS(lipopolysaccharide,1 ?g/kg) ig respectively in two model groups to induce liver injury. Liver injury was assessed by quantifying activities of plasma GPT, SOD, GSH-Px and MDA content.Results: The increase of plasma GPT activity was significantly inhibited by LMFO in two liver injury models, suggesting that LMFO had good protective effect on the hepatocytes. LMFO had good antioxidative effect in mice with liver injury induced by CCl 4 and D-GalN+LPS as indicated by decreased MDA content and increased activities of plasma SOD and GSH-Px. Conclusion: LMFO is protective against CCl 4-induced and D-GalN+ LPS induced liver injury in mice and its effect may be due to its antioxidative activities in vivo.
