Effect and mechanism of nitrary flavone on Hep,U_(14) tumor of mice
- VernacularTitle:沙樱桃黄酮对小鼠Hep、U14抑制作用及其机制探讨
- Author:
Farong YU
;
Keqiang WEI
;
Xiuzhen LIAN
- Publication Type:Journal Article
- Keywords:
nitrary flavone;
hepatic carcinoma clone (Hep);
carcinoma of uterine cervix 14 clone (U 14 );
mouse
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the inhibitory effect and mechanism of n itrary flavone in Hep and U 14 tumor. METHODS The Hep or U 14 tumor cells were injected in the armpit subcutaneous layer of right foreleg of BALB/c strain mice. After 24 h,nitrary flavone at a does of 100 mg?kg -1 ?d -1 body weight or combine nitrary flavone with 5-Fu(100 mg?kg -1 ?d -1 body weight)was given (ip) and inhibitory rate of nitrary flavone for transplanted tumor and the immune function of mice were determined. RESULTS Administration of nitrary flavone to mice for 10 consecutive days exhibited significantly the inhibitory rate for Hep and U 14 by 34 11%,32 14% and 50 73%,47 22%,respectively, as well as the weight of immune organs of mice, formation value of serolysin and phagociytic index were significantly enhanced(P
