Combination of neuroprotective agents inhibited neuron apoptosis in focal ischemic area of rat with MCAO
- VernacularTitle:联合应用神经保护剂抑制大鼠局灶性脑缺血后的神经元凋亡
- Author:
Zhimei LI
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
neuroprotective agents;
combination;
apoptosis;
caspase-3
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of therapy with different combined neuroprotective agents.Methods Using suture occlusion technique,the right middle cerebral artery in rats was occluded.All animals were randomly assigned before surgery to following groups: control group,FDP-treated group,MK-801-treated group,NAC-treated group,combination-treated group and sham operation group.The apoptosis of neurons was detected with TUNEL stained.The expression of caspase-3 was detected with immunohistochemistry and Westernblot.Results After(6) and(24 h) of cerebral ischemia,both apoptosis of neurons and the expression of caspase-3 in the combination-treated group were significantly decreased than those in single agent group(P
