THE CARDIOPROTECTIVE EFFECT OF ANTI ICAM-1 MONOCLONAL ANTIBODY ON MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN RATS
- VernacularTitle:抗细胞间粘附分子-1单克隆抗体对心肌缺血再灌注损伤的保护效应
- Author:
Hong WU
;
Qian SHEN
;
Tonghu ZHANG
- Publication Type:Journal Article
- Keywords:
myocardial ischemia;
reperfusion injury;
intercellular adhesion molecule 1;
antibody
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
The present study was designed to evaluate the effect of anti intercellular adhesion molecule 1(ICAM 1) monoclonal antibody in a rat model of myocardial ischemia reperfusion injury (I/R). Anaesthetized rats were subjected to total occlusion (45 min) of the left main coronary artery followed by 24 h reperfusion. The area of myocardial necrosis, myocardial function (such as LVSP, +P′max, LVEDP and -P′max) and PMN infiltration were measured. We found that the area of myocardial necrosis in treated rats was smaller than that in control group ( P
