EFFECT OF SUPEROXIDE DISMUTASE PLUS CATALASE ON PROTECTION OF GLOBALLY ISCHEMIC REPERFUSED ISOLATED RABBIT HEART
- VernacularTitle:超氧歧化酶和过氧化氢酶对缺血后再灌注心肌的保护
- Author:
Zhifei XU
- Publication Type:Journal Article
- Keywords:
oxygen free radical;
isolated rabbit heart,myocarclial protection
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
An experimental model of isolated rabbit working hearts was used to investigate whether supplementing cardioplegic solution with oxygen free radical scavengers exerts protective effect on ischemic and reperfusad heart.Animal hearts wero randomly divided into two groups : simple cardioplegic solution was used in the control group ; cardioplegic solution was supplemented with superoxide dismutase plus catalase in the experimental group.Following 120 min of ischemic arrest and 30 min of reperfusion, recoveries of LVPSP, LVEDP, LV + dp/dt max and LV-dp/dt max, expressed as percentage of preischemic control valu-S, and tissue ATP contjnt w-r significantly better (P
