INFLUENCE OF BERBERINE AND SODIUM NITROPRUSSIDE ON THE ACTION OF SEVERAL AGONISTS IN THE AORTIC STRIPS OF RABBITS
- VernacularTitle:用兔主动脉条研究小蘖碱和硝普钠对几种激动剂作用的影响
- Author:
Wenshu HU
;
Dongdong HUANG
;
Dachao FANG
;
Minxing JANG
- Publication Type:Journal Article
- Keywords:
Berberine;
Sodium nitroprusside;
Prazosin;
Phenylephrine;
Aortic strips;
?-adrenoceptor blocking action
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Berberine could reverse the phenylephrine-induced contraction of aortic strips of rabbits, but not those induced by histamine, serotonin and high-K. It showed no effect on the resting tension of the strips.Prazosin l ?M completely abolished the phenylephrine-induced contraction of the strips, but berberine 100 ?M could block 94 ? 9%.The IC50 of berberine and prazosin for phenylephrine-induced c-ontraction is 30 ?M and 0.2 ?M. The results suggest that the action of berberine is not similar to sodium nitroprusside, but is similar to prazosin, a selective ?1 adrenoceptor blocker, although its potency is less than prazosin.
