Case-control study of the polymorphisms of CYP2E1-RsaⅠ and GSTT1 genes and susceptibility to pancreatic cancer
- VernacularTitle:CYP2E1-RsaⅠ、GSTT1基因多态性与胰腺癌遗传易感性的病例对照研究
- Author:
Chaoxian ZHANG
;
Xiaofeng GUO
;
Xiaofang XU
- Publication Type:Journal Article
- Keywords:
pancreatic cancer;
CYP2E1-RsaⅠ;
GSTT1;
polymorphism;
smoking
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the combination of smoking with CYP2E1-RsaⅠ and GSTT1 genes polymorphisms and pancreatic cancer.Methods The genetic polymorphisms of CYP2E1-RsaⅠ and GSTT1 were analyzed by polymorphism-polymerase chain reaction(PCR) technique in peripheral blood leukocytes of 150 pancreatic cancer cases and 150 non-cancer controls.Results The frequency of CYP2E1-RsaⅠ(c1/c1) and GSTT1(-) was 38.7% and 69.3% in pancreatic cancer cases and 20.7% and 44.7% in healthy controls,respectively.Statistical tests showed significant differences in the frequencies between the two groups(?2=15.75,P
