The influence of compound glycyrrhizin on expression of HMB45,TNF-? and IL-6 in lesion of vitiligo guinea pig model
- VernacularTitle:复方甘草酸苷对白癜风豚鼠模型皮损区HMB45、TNF-?和IL-6表达的影响
- Author:
Rihua JIANG
;
Mingwei ZHOU
;
Jing SUN
- Publication Type:Journal Article
- Keywords:
Compound glycyrrhizin;
Vitiligo;
Animal model
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of compound glycyrrhizin on expression of HMB45,TNF-? and IL-6 in lesion of compound. using vitiligo guinea pig model induced by chemical decolorized compound.Methods:Two Guinea pig model groups were respectively treated with compound glycyrrhizin in 27.8 mg/kg and 55.6 mg/kg dosage. Immunohistochemical studies were performed to study the expression of HMB45,TNF-? and IL-6 in compound glycyrrhizin treated group,vitiligo model group and normal control group.Results:The expression of HMB45 in lesion of vitiligo model group was lower than the normal control group.The expression of HMB45 in lesion of compound treated group was higher than the vitiligo model group and the expression of HMB45 increased accompany by the increase of dosage.The expression of TNF-? and IL-6 in vitiligo model group was significantly higher than the normal control group (P
