NGF、BDNF gene modified bone marrow stem cells transplantation with vein on spinal cord injnry
- VernacularTitle:NGF、BDNF基因修饰的BMSCs静脉注射治疗脊髓损伤
- Author:
Lin BU
;
Huan ZHONG
;
Hanguo JIANG
- Publication Type:Journal Article
- Keywords:
genetic modification;
bone marrow stem cells;
transplantation with vein;
spinal cord injury
- From:
Orthopedic Journal of China
2006;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To study NGF,BDNF gene modified bone marrowe stem cells transplantation with vein on spinal cord injury.[Method]Spinal cord injured rats were divided in to 3 groups.Group C consisted of the rats treated with the transplantation of modified NGF,BDNF genes BMSCs;group B of the rats with transplantation of BMSCs without genetic modification;group A of the rats without treatment and group D was the normal contral.At 2,6,10 weeks the rats were examined with GBS score and neurological function were tested.[Result]The vein with tintracord transplantation of modified BMSCs group was improved by the GBS score and neurological outcome of injured spinal cord was achieved well.[Conclusion]The vein with transplantation of modified NGF,BDNF genes BMSCs can recover of spinal cord injury.
