Study on the expression of PTEN and P53 in human primary gallbladder carcinoma(HGC)
- VernacularTitle:原发性胆囊癌中PTEN和P53基因表达的研究
- Author:
Ying HUANG
;
Changli ZHENG
- Publication Type:Journal Article
- Keywords:
primary gallbladder carcinoma;
P53;
PTEN;
immunochemistry;
in situ hybridization
- From:
China Oncology
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:To study the expression of PTEN and P53 and analyse their roles in HGC oncogenesis,and to discover a good marker for diagnosis and prognosis of HGC.Methods:The expression of PTEN mRNA,PTEN protein and P53 protein were detected by in situ hybridization(DNA-RNA) and immunohistochemistry(SP method) in 64 cases of HGC.We took 22 cases of gallbladder adenoma and 10 cases of chronic cholecystitis as controls.Results:① The positive expression rates of PTEN mRNA and protein in HGC(56.3%,59.4%) were significantly lower than that in gallbladder adenoma(81.8%,90.8%) and chronic cholecystitis(100%,100%)(P
