Expression of cyclooxygenase-2 in colorectal cancer and its clinical significance
- VernacularTitle:环氧化酶-2在结直肠癌组织中的表达及其临床意义
- Author:
Shaohui CHENG
;
Yang WANG
;
Junhua LEI
- Publication Type:Journal Article
- Keywords:
Colorectal carcinoma;
Cyclooxygenase-2(COX-2);
Immunohistochemistry;
Carcinogenesis
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of cyclooxygenase-2(COX-2) in colorectal carcinoma tissues,and understand its clinical significance.Methods:The immunohistochemistry was used to determine the expression of COX-2 in the 43 tissues of colorectal cancer and 14 tissues of normal mocusa.Results:Positive expression of COX-2 was detected in 83.72% of colorectal cancerous tissues and in 14.29% of normal tissues and there was significant difference in expression of COX-2 between cancer tissues and normal tissues(P0.05).Conclusion:COX-2 was overexpressed in colorectal carcinoma.COX-2 maybe play an important role in carcinogenesis and progression of colorectal carcinoma.
