The expression of receptor for advanced glycation end product in gingival tissues of type 2 diabetic patients with periodontitis
- VernacularTitle:晚期糖基化终末产物受体在2型糖尿病伴牙周炎患者牙龈中表达
- Author:
Xiaoqian YU
;
Yueqin SHA
;
Rongkun LIU
- Publication Type:Journal Article
- Keywords:
Receptor for advanced glycation end products;
Non-insulin dependent diabetes mellitus;
Periodontitis
- From:
Journal of Practical Stomatology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the distribution of the receptor for advanced glycation end products(RAGE) in gingival tissues of patients with non-insulin dependent diabetes mellitus(NIDDM) accompanying periodontitis.Methods:5 patients with chronic periodontitits(CP) and 4 patients with NIDDM accompanying periodontitis were included. Immunohistochemical staining was performed to detect RAGE and tumor necrosis factor ?(TNF-?) expression in gingival tissues.Interleukin 6(IL-6) and TNF-? levels in gingival crevicular fluid and serum of these patients were examined by ELISA.Results:More RAGE cells were observed in the gingival tissus in the patients of NIDDM with CP than in those of CP(P0.05).Conclusion:RAGE may play a role in the destruction of periodontal tissues in NIDDM patients with CP.
