EFFECTS OF BERBERINE ON PLATELET AGGREGATION AND RELEASE
- VernacularTitle:黄连素对血小板聚集和释放的抑制作用
- Author:
Zhonglu CHU
- Publication Type:Journal Article
- Keywords:
berberinc;
antiplatelet drug;
platelet inducer;
platelet shape change,platelet aggregation;
platelet release reaction
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
We have discovered that bcrberine (BR) is an anti-platelet drug.It was demonstrated that BR inhibited ADP-, arachidonate-, collagen-and calcium ionophorc A231S7-xnduced platelet aggregation and ATP release in different degrees.Especially BR strongly inhibited collagen-induced platelet aggregation and ATP release reaction(IC50 values were 0.12 and 0.08 mmol/L,respectively).The antiplatekt mechanism of BR may be inhibition of arachidonate metabolism,, and suppression of the rise of intracdlular Ca2' and/or cAMP levels.Because the platelet thrombus foimation in the arteries of brain and heart is closely related to the subendothelial collagen fibrils, BR may be an effective drug for the patients with these diseases.
