The protective effect of Salvia Miltiorrhizae on renal mitochondria in rats with obstructive jaundice
- VernacularTitle:丹参对梗阻性黄疸肾脏线粒体保护作用的实验研究
- Author:
Xuting ZHI
;
Tao LI
;
Fengjun LIU
;
Kesen XU
- Publication Type:Journal Article
- Keywords:
Cholestasis?Kidney?Mitochondria?Salvia Miltiorrhiza
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of oxygen free radicals in renal dysfunction in rats with obstructive jaundice and the protective effect of Salvia Miltiorrhiae(SM) on renal mitochondria.Methods:The 54 Wistar rats were randomly divided into three groups:sham-operation control group(group A,n=18),obstructive jaundice group(group B,n=18),SM-treated group(group C,n=18).The model of obstructive jaundice in rats was established by common bile duct ligation(CBDL).In group C SM(5ml/kg?d) was given through abdominal cavity for 21 days.The rats were executed at 7th,14th,and 21th day after operation respectively.The contents of serum BIL,Cr,BUN and the contents of renal mitochondria MDA and cholesterol were determined respectively,and the changes of renal histopathology were observed.Results:The contents of renal mitochondria MDA and cholesterol in group B and group C were markedly higher than group A(P
