Changes of BDNF level expression in Hippocampal and Habenular nucles in experimental depression rats
- VernacularTitle:实验性抑郁症大鼠缰核和海马BDNF基因表达
- Author:
Wei XIA
;
Hua ZHAO
;
Aihua REN
;
Weigao SHEN
- Publication Type:Journal Article
- Keywords:
Depression;
Hippocampal;
Habenular nucles(Hb);
Brain-derived neurotrophic factor,BDNF
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the change of BDNF level expression in experimental in hippocampal and habenular nucles in experimental depression rats.Methods:The depression model of rats was established by chronic unpredictable mild stress. Openfield test was performed to detect the behavior of rats. Immunohistochemistry was used to observe the changes of BDNF level.Results:Compared to the control group,the number of depressed animals was much less than that of normal animals.Conclusion:The level of BDNF decrease significantly in experimental depressive model of rats.
