Effect of D-galactose on parameters for skin aging in murine model
- VernacularTitle:D-半乳糖致衰老模型小鼠皮肤衰老的观察
- Author:
Hongli WANG
;
Tie WU
;
Jubiao QIAN
;
Jun WU
;
Qijie GUO
- Publication Type:Journal Article
- Keywords:
Skin aging;
Galactose
- From:Chinese Journal of Geriatrics
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate parameter changes for skin aging in murine model induced by D-galactose. Methods Sixty 3-month-old female mice were randomly divided into three groups: normal control group,low dose (80 mg/kg)and high dose (1000 mg/kg) D-galactose groups. After subcutaneous administration for 6 weeks, the aging models were established. Then, histochemical standards relating to aging were measured and morphologic alterations of surplus dorsal skin were observed under microscope and analyzed. Results In contrast with the control group, high dose D-galactose group showed that the thickness of dermis (624.5 ?48.5) ?m was significantly reduced (P
