Toxicity of levodopa and dopamine on PC12 Cells and neuroprotective effect of several anti-Parkinson drugs on the toxicity
- VernacularTitle:左旋多巴和多巴胺对PC12细胞的毒性及其他抗帕金森病药物的神经保护作用
- Author:
Qin XIAO
;
Shengdi CHEN
;
Jian FEI
- Publication Type:Journal Article
- Keywords:
Levodopa;
Dopamine;
Parkinson disease
- From:
Chinese Journal of Geriatrics
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the toxicity of levodopa and dopamine on PC12 cells and neuroprotection of several anti-Parkinson drugs i.e. amantadine,pergolide and selegiline. Methods The possible cytotoxicity of levodopa and dopamine at different dosage on rat pheochromocytoma PC12 cells and the effects of some anti-Parkinson drugs (amantadine,pergolide and selegiline) on levodopa- or dopamine-induced cytotoxicity were determined by MTT assay and flow cytometry. Results There was a concentration- and time-dependent decrease in cell viability and a concentration-dependent increase in apoptotic cells induced by levodopa and dopamine ( P
