Protective effect of Ginkgo biloba extract on acute lung injury in aging rats and renal function damage induced by acute lung injury
- VernacularTitle:银杏叶提取物对衰老大鼠急性肺损伤和肾功能受损的保护作用
- Author:
Ying SUN
;
Renyu SUN
;
Yewei DU
;
Shiwen WANG
- Publication Type:Journal Article
- Keywords:
Multiple organ failure;
Lipopoly saccharides;
Anti-aging drugs(TCD);
Cingko biloba
- From:Chinese Journal of Geriatrics
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether gingko biloba extract (GBE) have protective effect on acute lung injury(ALI)induced by Lipopolysaccharide ( LPS) in aging rats and renal function damage induced by ALI. Methods Male aging Wistar rats(36) were used in the study. LPS group (LPS, iv route, 5mg/kg body weight) and GBE+LPS group (GBE was given starting from 7 days before experiment, once a day oral administration). The blood, lung and kidney samples were collected at 2 or 6 hours after LPS or saline administration. Results Compared with the aging control, ALI was obviously observed in LPS group, blood creatinine and urea nitrogen were increased significantly from (68.7? 6.9) mol/L and (5.9?0.6) mmol/L to (94.7?10.3) mol/L and (11.4?1.9) mmol/L, respectively (P
