Protective role of benazepril in renal tubulo-inter stitial injury in diabetic rat
- VernacularTitle:苯那普利对糖尿病大鼠肾小管间质损伤的保护作用及机制
- Author:
Yonggui WU
;
Shanyan LIN
;
Jianghua ZHOU
;
Yong GU
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
Renal tubuloint erstitium;
Benazepril
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Uninephrectomy was performed in a ll rats of this study, and diabetic model was induced in partial rats by streptozo tocin. Then these rats were divided into uninephrectomy group, diabetes group an d benazepril-treated diabetes group. After 4 weeks, renal tubulo-interstitial morphological change was observed and type Ⅳ collagen, fibronectin and transfor ming growth factor ? 1 (TGF-? 1) proteins as well as TGF-? 1 mRNA were d etermined. The results suggested that benazepril played a protective role in ren al tubulo-interstitial injury, which was associated partially with down-regula ted overexpression of TGF-? 1.
