Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression in hilar cholangiocarcinoma
- VernacularTitle:肝门胆管癌基质金属蛋白酶MMP-2及其组织抑制因子TIMP-2表达及意义的研究
- Author:
Fuquan YANG
;
Xianwei DAI
;
Haiying ZHAO
;
Liang WANG
- Publication Type:Journal Article
- Keywords:
Hilar cholangiocarcinoma;
Matrix metalloproteinase-2;
Tissue inhibitor of metalloproteinase-2
- From:Chinese Journal of Current Advances in General Surgery
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in hilar cholangiocarcinoma.To discuss the relationship of MMP-2 and TIMP-2 expression with the metastasis and prognosis of hilar cholangiocarcinoma.Methods:Immunohistochemical S-P method was used in the examination of MMP-2 and TIMP-2 expression in 78 hilar cholangiocarcinoma.The relationships of MMP-2 and TIMP-2 expression with the pathological differentiation,metastasis and prognosis were analyzed.Results:The positive rate of MMP-2 expression was 72% ,and that of TIMP-2 was 76%.According to Ridit analysis,the degree of MMP-2 expression were correlated with the pathologic differentiation and lymph-node metastasis of hilar cholangiocarcinoma.The high expression of MMP-2 existed in the low pathologic differentiation and the high rate of lymph-node metastasis of hilar cholangiocarcinoma.The high expression of TIMP-2 existed in the high pathologic differentiation and the low rate of lymph node metastasis of hilar cholangiocarcinoma. MMP-2 and TIMP-2 expression had a significance correlation(r=0.708,P
