Clinical study of one Chinese pedigree with glucocorticoid-remediable aldosteronism
- VernacularTitle:糖皮质激素可治性醛固酮增多症——一个中国人家系的临床研究
- Author:
Wei DING
;
Libin LIU
;
Manyin XU
- Publication Type:Journal Article
- Keywords:
Hyperaldosteronism;
Aldosterone;
Renin;
Glucocorticoids;
Glucocorticoid remediable aldosteron
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To report the clinical characteristics, biochemical profiles, diagnosis and treatment of one Chinese pedigree with glucocorticoid remediable aldosteronism. Methods Plasma and urine aldo~sterone and cortisol and plasma renin activity were dynamically tested and diagnostic therapy was undergone in 3 affected subjects. Results All of 4 affected members had hypertension, hypokalemia, 3 patients had low basic and provoked renin activity (0.017?0.015 vs 0.13?0.08)?g?L -1 ?h -1 . 3 patients were treated with 2 mg dexamethasone for 5～7 days, then the medication was reduced gradually and maintained at 0.5～0.75 mg per day after 1～1.5 month(s). 5 days after treatment, the plasma aldosterone concentrations (PACs) decreased significantly from (192?9)ng/L to (87?7)ng/L (P
