EFFECT OF TOTAL FLAVONES OF HIPPOPHASE RHAMNOIDES ON ISOLATED VASCULAR SMOOTH MUSCLES
- VernacularTitle:沙棘总黄酮对离体血管平滑肌的作用
- Author:
Xiaojiang YU
;
Chuangao LIU
;
Xiaoguang LI
- Publication Type:Journal Article
- Keywords:
total flavoncs of hippophase rhamnoides;
calcium channel blocker, aortic preparations
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Total flavones of hippophase rhamnoides (TFH) inhibited the contraction of isolated rabbit aortic preparations induced by KCl, CaCl_2 and noradrenaline (NE), shifted the dose-response curvesto the right and depressed the maximal response. PD_2' values were 5.79, 5.75 and 5.81 respectively. TFH could also reduce Ca~(2+) -dependent contraction in rabbit aortic preparations. These results suggest that relaxation of vascular smooth muscles caused by TFH may be due to TFH natagonistic effect on transmembrane Ca~(2+) channels.
