CLINICAL SIGNIFICANCE OF CHANGES OF ATRIAL NATRIURETIC POLYPEPTIDE (ANP) IN PRIMARY ALDOSTERONISM AND THEIR RELATION WITH THE "ESCAPE PHENOMENON
- VernacularTitle:原发性醛固酮增多症中血浆心钠素变化的临床意义及其与脱逸现象的关系
- Author:
Menyin XU
- Publication Type:Journal Article
- From:Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Plasma ANP was significantly increased in 20 cases of primary aldosteronism as compared with 21 controls, and the ANP levels were positively correlated with those of plasma aldosterone and blood pressure readings. The increased ANP returned to normal after the aldosterone-secreting adrenal tumor had been removed. It was found that sodium excreted in urine was negatively correlated with plasma as well as urinary aldosterone, but was positively correlated with ANP / plasma aldosterone or ANP / urinary aldosterone ratio. It might be suggested that increased ANP should be a compensatory reaction to the overproduction of aldosterone and might play a role in the development of "escape phenomenon" in primary aldosteronism.
