Protective Effects of Rosiglitazone Maleate on Renal Ischemia-Reperfusion Injury in Mice and Its Mechanism
- VernacularTitle:马来酸罗格列酮对肾缺血再灌注损伤模型小鼠的保护作用及其机制研究
- Author:
Yuanfang WANG
;
Guangda SHAO
;
Yunbo LIU
- Publication Type:Journal Article
- Keywords:
Rosiglitazone maleate;
Renal ischemia-reperfusion;
Mice;
Anti-oxidation
- From:
China Pharmacy
2007;0(29):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the protective effects of rosiglitazone maleate on renal ischemia-reperfusion injury in mice and its mechanism.METHODS: 30 mice were randomly divided into sham operation group(normal saline),model group(normal saline) and rosiglitazone maleate group(rosiglitazone maleate 5 mg?kg-1?d-1).Three groups received relevant drugs for 10 days.Renal ischemia-reperfusion injury model was induced in model group and rosiglitazone maleate group by clipping the renal pedicle 40 minutes after the last administration.The renal index,the content of blood urea nitrogen(BUN) and creatinine(Cr),the content of malondialdehyde(MDA),the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) in renal tissue were detected.Pathological change of renal tissue was observed by HE stain.RESULTS: Compared with model group,the renal index of the mice in rosiglitazone maleate group reduced(P
