Protective effects of bone marrow mesenchymal stem cells against the renal tubular epithelial cell damage induced by cisplatin
- VernacularTitle:骨髓间充质干细胞共培养减轻顺铂所致的肾小管上皮细胞损伤
- Author:
Jun WANG
;
Fengxian HUANG
;
Xueqing YU
- Publication Type:Journal Article
- Keywords:
Kidney failure,acute;
Bone marrow mesenchymal stem cells;
Renal tubular epithelial cells;
Cisplatin
- From:Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the protective effects and mechanism of mesenchymal stem cells on renal tubule cells treated by cisplatin.METHODS:The mesenchymal stem cells(MSCs)were separated from mouse bone marrow.The necrosis and apoptosis rate of renal tubule cells induced by cisplatin were detected by flow cytometry.After co-culture with MSCs,the above changes of renal tubule cells were detected.RESULTS:In co-culture system,the apoptotic rates of renal tubule cell were decreased obviously and the cell number increased obviously.CONCLUSION:The MSCs protect the renal tubule cells from apoptosis induced by cisplatin.This effect may be related with the paracrine effects of MSCs.
