Neuroprotective Effect and Anticoagulation Effect of Total Saponins of Radix Liriopes on Focal Cerebral Ischemia
- VernacularTitle:山麦冬总皂苷对局灶性脑缺血损伤的保护及抗凝血作用研究
- Author:
Sa DENG
;
Weiping LI
;
Kaihuan REN
;
Qin ZHOU
;
Lisong YANG
;
Guozhu HAN
- Publication Type:Journal Article
- Keywords:
Middle cerebral artery thrombosis model;
Focal cerebral ischemia;
Total Saponin of Radix Liriopes;
Blood coagulation
- From:
China Pharmacy
2007;0(30):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the neuropotective effect and anticoagulation effect of total Saponins of Radix Liriopes on focal cerebral ischemia in rats.METHODS:Chemical reagent Fecl3 was locally applied on the injured vessels to establish middle cerebral artery thrombosis model,and the effects of total Saponins of Radix Liriopes on rats' behavioral disturbance,brain infarct size,the histopathological changes in brain and the expression rate of nNOS immunoreactive positive neurons were measured,and the bleeding time and coagulation time were also detected with glass tube method and tail transection method.RESULTS:Due to the use of total Saponin of Radix Liriopes(10 and 40mg? kg-1),the brain infarct size was significantly decreased,the behavioral disturbance were improved and the expression rate of the nNOS immunoreactive positive neurons in rats were decreased.At doses of 20 and 60mg? kg-1,total Saponin of Radix Liriopes significantly prolonged the coagulation time and bleeding time.CONCLUSION:Total Saponin of Radix Liriopes has nuroprotective effect on focal cerebral ischemia induced by middle cerebral artery thrombosis and significant anticoagulation effect.
