Effects of Total Flavone of A on Post-stroke Depression in Rats
- VernacularTitle:黄蜀葵总黄酮抗脑卒中后抑郁作用的研究
- Author:
Jili HAO
;
Lanlan ZHOU
;
Qiuhong JIANG
;
Ying MA
;
Haiyan YAN
- Publication Type:Journal Article
- Keywords:
Total flavone of A;
Post-stroke depression;
Open- field test;
Hemorheology;
Lipid peroxidation
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the antidepressant effects of total flavone of A( TFA) on post stroke depression ( PSD) in rats. METHODS: Middle cerebral artery occlusion ( MCAO) followed by isolation feed and irritable stimuli was used to induce PSD. Behaviours of rats were detected by open- field test . The effects of TFA on the indexes of hemorheology and brain homogenate lipid peroxidation were also tested. RESULTS: TFA could increase the crossing and rearing scores in open- field test, inhibit the elevation of whole blood viscosity as well as plasma viscosity at high- middle- low shear rates, increase the erythrocyte deformation, enhance the activities of Superoxide Dismutase ( SOD) and Glutathione Peroxidase ( GSH- Px) , and reduce Malondialdehyde ( MDA) content in brain homogenate in PSD in rats. CONCLUSIONS: TFA produces an antidepressant- like effect in PSD rats. This mechanism may be in association with attenuating hemorheological parameters and decreasing lipid peroxidative damage.
