Rapamycin Combined with Cyclosporine in the Prevention of Acute Renal Allograft Rejection:Randomized Prospective Control Study
- VernacularTitle:雷帕霉素联合环孢素预防肾移植急性排斥反应的随机对照前瞻性研究
- Author:
Bin LIU
;
Changsheng MING
;
Fanjun ZENG
;
Weijie ZHANG
;
Zhishui CHEN
;
Zhengbin LIN
;
Dungui LIU
- Publication Type:Journal Article
- Keywords:
Rapamycin;
Azathioprine;
Ciclosporin;
Renal transplantation;
Immunosuppress;
Rejection
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To evaluate the efficacy of rapamycin(RPM)oral liquid plus cyclosporine(CsA)on the preven?tion of early acute rejection after renal allograft.METHODS:20patients undergoing primary renal allografting were randomly divided into RPM trial group and Azathioprine(Aza)control group,10cases in each group,who were respectively assigned to receive CsA and adrenocortial hormones-based immunosuppression for6months,indexes including survival rates of recipients/kidneys,incidences of acute rejection and adverse reactions between2groups were compared.RESULTS:For the17patients who had finished6-month treatment,the survival rates(recipients/kidneys)were100%.Only2episodes of acute rejection occurred in one case in Aza group.Both groups had2cases of severe adverse episodes.CONCLUSIONS:The combined therapy pf RPM plus CsA is effective in the prevention of acute renal allograft rejection,and it can maintain renal function at a good level.Nevertheless,it may increase the hepatotoxicity of CsA.
