Correlation between the signal pathway IKK/NF-?B and the anti-oxidant activity in asthma rats and the modulation of Ginkgo biloba extract
- VernacularTitle:哮喘大鼠IKK/NF-?B信号通道与抗氧化性的关系及银杏叶提取物的调控
- Author:
Yiping LIN
;
Changchong LI
;
Ye HU
;
Mengrong LI
;
Yufei MAO
;
Xiaofang CHEN
- Publication Type:Journal Article
- Keywords:
Asthma;
NF-kappa B;
Malondialdehyde;
Ginkgo biloba
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the correlation between the signal pathway of IKK/NF-?B and the anti-oxidant activity in asthmatic rats and the modulation of Ginkgo biloba extract (Egb). METHODS: Thirty-six male SD rats were randomly divided into three groups: control group (group C), asthmatic group (group A) and Egb group(group E). Asthma in rats was established by ovalbumin (OVA) challenge methods. The mRNA of IKK? and the protein of NF-?B P65 in lung tissue were assessed by using in situ hybridization with oligonucleotide probe and immunohistochemisty, respectively. RESULTS: The expression of IKK? mRNA and NF-?B P65 protein in group A were significantly increased when compared with group C (P
