Role of heme oxygenase-1 in cardioprotection against anoxia/reoxygenation induced injury and its mechanisms
- VernacularTitle:HO-1在保护缺氧-复氧心脏中的作用及其机制研究
- Author:
Yang WANG
;
Youai DU
;
Hejing XU
;
Wei GUO
;
Yingying CHEN
;
Yueliang SHEN
- Publication Type:Journal Article
- Keywords:
Heart;
Anoxia;
Heme oxygenase (decyclizing);
Cyclooxygenase-2
- From:Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the role of HO-1 in protection of rat hearts against anoxia/reoxygenation-induced injury and its underlying mechanism. METHODS: Cardiac contractility, lactate dehydrogenase (LDH) and infarct area were analyzed by the Langendorff method in isolated rat hearts. RESULTS: After intraperitoneal injection of HO-1 inducer hemin, CO concentration in rat blood enhanced (P
