Determination of Fas molecules on T cells and its relation with the reactiveness of SLE and therapeutic effect
- VernacularTitle:T细胞表达Fas用于评价系统性红斑狼疮活动性和疗效的价值
- Author:
Shuangquan GAO
;
Furong LI
;
Hui QI
;
Xuel XIAO
;
Lili REN
;
Xingen WANG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
Fas molecules;
T cells;
Apoptosis
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To determine the expression level of Fas molecules on the T cells isolated from systemic lupus erythematosus (SLE) patients. METHODS: The expression of Fas on T cells and the apoptotic rate of 36 patients with SLE in active phase and 18 normal people were determined with flow cytometry. The patients were treated with impact therapy of prednisone, methylprednisolone or cyclophosphamide, respectively, according to their conditions. Within 3 days after admission, immediately before discharging (the average days in hospital is 22.6 d), and 4 weeks after discharging, the amount of Fas molecules expressed on T cell surface was determined respectively with flow cytometry in each patient. RESULTS: There was a positive correlation between SLEDAI, apoptotic rate of T cells and Fas molecules on T cells in SLE patients of active phase (P
