Suppressive effect of glycyrrhizin on murine contact hypersensitivity
- VernacularTitle:甘草甜素抑制小鼠接触性超敏反应的实验研究
- Author:
Jun SHI
;
Yaoying ZENG
;
Xiaochang CAI
;
Xiangfeng ZENG
;
Min YI
;
Lin CONG
- Publication Type:Journal Article
- Keywords:
Glycyrrhiza uralensis;
Dermatitis, contact;
Dinitrofluorobenzene;
Thymus gland;
Spleen
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the suppressive effect of glycyrrhizin (GL), a Chinese medicine, on DNFB-induced contact hypersensitivity in mice. METHODS: BALB/c mice were divided into 5 groups according to different medication: GL 1 (11 mg/kg) group; GL 2 (22 mg/kg) group; GL 3 (44 mg/kg) group; dexamethasone (DXM, 0.75 mg/kg) group; and normal saline group. For induction of contact hypersensitivity (CHS) to DNFB, mice were sensitized to abdomen and challenged to right ear by epicutaneously DNFB. Each mouse was administrated intraperitoneally on day 1 to day 5 with different medication. The suppression of mice CHS by different medication were evaluated 24 hours after elicited, according to ear thickness difference, ear weight difference and pathological change of challenged ear section. Thymus index and spleen index were calculated to see the effect on mouse immune system to CHS. RESULTS: Compared with normal saline group, the ear thickness difference and ear weight difference were both significantly reduced in GL1, GL2, GL3 and DXM groups (P
