Clinical Observation on Hepatoprotective Effect of Compound Glycyrrhizin in Treating Patients with Multidrug Resistant Pulmonary Tuberculosis
- VernacularTitle:复方甘草酸苷在耐多药肺结核患者抗结核治疗过程中的保肝作用临床观察
- Author:
Weimin DING
;
Junxing YANG
;
Jihai ZHENG
;
Guanghui WANG
- Publication Type:Journal Article
- Keywords:
Compound glycyrrhizin;
Pulmonary tuberculosis;
Multidrug resistance;
Lesion of liver function
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the hepatoprotective effect of compound glycyrrhizin in treating patients with multidrug resistant pulmonary tuberculosis(MDR-TB).METHODS:A total of 68 MDR-TB cases were enrolled:36(treatment group) were randomly assigned to receive additional glycyrrhizin,and 32(control group) to receive additional glucurolactone and legalon,the hepatoprotective effects and side effects between 2 groups were compared before and after treatment.RESULTS:The total effective rates of the treatment group and the control group were 94.4% and 62.5%,respectively 1month after hepatoprotective treatment,and significant difference was noted between 2 groups(P0.05).CONCLUSION:Compound glycyrrhizin has a reliable hepatoprotective efficacy and few adverse drug reactions in treating MDR-TB patients complicating with lesion of liver function.
