Effects of advanced glycation endproducts on proliferation of pericytes of bovine retinal capillary vessels and expression of transforming growth factor ?
- VernacularTitle:糖基化终末产物对牛视网膜毛细血管周细胞增殖及转化生长因子-?表达的影响
- Author:
Yuehui WANG
;
Jinsong NI
;
Lanyue CHEN
- Publication Type:Journal Article
- Keywords:
Glycation end products,advanced/diagnostic use;
Diabetic retinopathy/physio-pathology;
Transforming growth factors ?;
Retina/drug effects;
Pericytes
- From:Chinese Journal of Ocular Fundus Diseases
1996;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of advanced glycation endproducts (AGEs) on proliferation of pericytes of bovine retinal capillary vessels and expression of transforming growth factor ?(TGF-?). Methods [WTBZ]The proliferation of pericytes detected by methyl thiazolyl tetrazolium (MTT) colorimetric assay, cellular cycle of pericytes was analyzed by flow cytometry was used to analyze cell, and TGF-? protein expression of pericytes was observed by immunofluorescent staining. Results AGEs inhibited the proliferation of pericytes of bovine retinal capillary vessels, stopped the cellular cycle of pericytes in synthesis phase (S phase), increased the number of apoptotic cells obviously (P
