Protective Effects of Neurotrophin-3 on The Excitotoxic Damage of Cochlear Afferent Neurons in Guinea Pigs
- VernacularTitle:神经营养素-3对豚鼠耳蜗传入神经元兴奋毒性损伤的保护作用
- Author:
Yongquan ZHANG
;
Ming JIANG
;
Hong SUN
- Publication Type:Journal Article
- Keywords:
Neurotrophin-3;
Glutamate;
Spiral ganglion;
Cochlea;
Guinea pig
- From:
Journal of Audiology and Speech Pathology
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). Conclusion 1. Exogenous glutamate application via scala tympani can result in a rapid excitotoxic damage of cochlear typeⅠspiral ganglion cells of guinea pigs. 2. NT-3 can protect typeⅠspiral ganglion cell from glutamate neurotoxicity even applied 60 minutes after the occurrence of glutamate induced cochlear impairment. The result indicates that NT-3 may be an ideal candidate for the treatment of a series of acute neural hearing loss.It may lead to a better outcome when NT-3 gene therapy is actilized.
