Effects of epidural capsaicin with different contrention on pain threshold and nerve tissue structure in rats
- VernacularTitle:硬膜外不同浓度辣椒辣素对大鼠痛阈及脊神经根组织结构的影响
- Author:
Yingwei DONG
;
Yiwei WANG
;
Weiliang CHU
- Publication Type:Journal Article
- Keywords:
Capsaicin;
Injections,epidural;
Pain threshold;
Spinal nerve root;
Pathology
- From:
Chinese Journal of Anesthesiology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of epidural capsaicin on pain threshold and nerve tissue structure in adult rats. Methods Twenty-four adult male Wistar rats weighing 250-300 g were used in this study. A catheter was inserted into epidural space at L5,6 according to the method of Philippe. 0.4 ml of capsaicin 0.1% (group A), 0.25% (group B) or 0.5% (group C) or 10% Tween 80 (control group) was injected via the epidural catheter. Pain threshold was measured by thermal stimulation of the tail before (baseline) and on the 3rd, 7th and 14th day after epidural capsaicin. The animals were then killed. The lumbar segment (L4-6) of the spinal cord and spinal nerve roots were removed immediately for light and electron microscopic examination. Results Pain threshold was significantly higher in group A, B and C than in control group (P
