Effects of Chinese medicine SMⅠon learning and memory ability and hippocampal BDNF expression in mice with Alzheimer's disease
- VernacularTitle:中药复方SMⅠ对拟老年痴呆小鼠学习记忆能力及海马BDNF表达的影响
- Author:
Xiaoyan WANG
;
Jun DONG
;
Daxiang LU
;
Yongmei FU
;
Sanqiang PAN
;
Changsha YANG
- Publication Type:Journal Article
- Keywords:
Learning;
Memory;
Hippocampus;
Brain-derived neurotrophic factor;
Alzheimer disease
- From:Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: The goal of this study was to investigate the effect of a traditional Chinese medicine SMⅠon learning and memory ability in mice with Alzheimer's disease (AD) and its possible mechanisms. METHODS: The mice were treated with D-galactose and AlCl 3 to establish the AD animal model. D-galactose was given through intraperitoneal route for 62 days and AlCl 3 was given through intragastric route for 106 days. Since the 67th day, the mice in SMⅠgroup were treated with SMⅠ. The SMⅠtreatment continued for 40 days. Subsequently, the water maze test was applied to evaluate the effect of SMⅠon the AD model mice. At the last test day, the animals were killed and brain tissues were separated, and the expression of brain-derived neurotrophic factor (BDNF) in mice hippocampus was observed by reverse transcription polymerase chain reaction (RT-PCR). RESULTS: By intragastric administration with SMⅠ, mice had shorter latency ( P
