The Effect of Hyperglycemia on the Prognosis of Acute Lymphocytic Leukemia during Induction Chemotherapy
- VernacularTitle:诱导化疗期高血糖对急性淋巴细胞白血病预后的影响
- Author:
Dengming HU
;
Haibing JU
;
Huiying YING
- Publication Type:Journal Article
- Keywords:
Induction chemotherapy;
Hyperglycemia;
Acute lymphocytic leukemia
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of hyperglycemia on the survival time, duration of disease remission and complications during induction chemotherapy for acute lymphocytic leukemia(ALL). Methods The treatment-related complications in 98 adult ALL patients with or without hyperglycemia were retrospectively analyzed. Survival time and complete remission duration(CRD) were evaluated using Kaplan-Meier method. Cox regression analysis was used to examine whether hyperglycemia was an independent predictor of disease recurrence and death. Results ALL patients with hyperglycemia were found to be older, and more likely to occur thrombocytopenia. ALL patients with hyperglycemia had a shorter CRD and survival time, and were more likely to develop infection and neuropathy. Conclusion Hyperglycemia during induction chemotherapy for ALL increased the frequency of infection and the risk of disease recurrence and death.
