Effects of pueraria lobata isoflavones on myocardiac cell hypertrophy induced by neuropeptide-Y in vitro
- VernacularTitle:葛根总黄酮对离体神经肽Y诱导的心肌细胞肥大的影响
- Author:
Hong YAO
;
Shaohua HUANG
;
Ziren SU
- Publication Type:Journal Article
- Keywords:
Pueraria;
Neuropeptide Y;
Hypertrophy, myocardium
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of pueraria lobata isoflavones (PLIs) on neuropeptide-Y(NPY)-induced myocardiac cell hypertrophy in vitro. METHODS: Rat cardiomyocytes cultured in vitro were randomized to control, NPY, NPY+PLIs and PLIs group. The protein synthesis in cardiomyocytes was assessed by [~3H-Leu] uptake, C-jun mRNA by RT-PCR and CaN activity by histochemistry. RESULTS: The rate of [~3H-Leu] uptake, the C-jun mRNA expression and the CaN activity of myocardiac cells in 100 nmol/L NPY group were higher than those in control (P
