Determination of in Vitro Adhesion and Dissolution Rate of Total Puerariae Flavones(TPF)Bioadhesive Sustained-release Tablets
- VernacularTitle:葛根总黄酮生物粘附性缓释片体外组织粘附力及释放度研究
- Author:
Daxiong XIANG
;
Huande LI
;
Hongbo YUAN
- Publication Type:Journal Article
- Keywords:
total puerariae flavones;
bioadhesive sustained-release tablet;
dissolution rate;
bioadhesion
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the dissolution rate of total puerariae flavones(TPF)bioadhesive sustained-release tablet,and to determine its bioadhesive force to animal stomach and small intestine in vitro METHODS:Using rotating basket method,the dissolubility summation was determined with 0 1mol/L HCl as dissolution medium at speed of 100r/min,single-index model,Weibull distributing model,Higuchi equation and zero-class model were used to imitate the dissolution curve The biggest absolute error,the biggest relative error and AIC were used as comprehensive indices to select the best imitating model A new apparatus made by ourselves was used to compare the adhesive force between the sustained-release tablets and popular tablets in adhering to rabbits'stomach or small intestine RESULTS:The results showed that the dissolution rate in vitro imitated in single-index model was the best Bioadhesion study showed that there were obvious differences between bioadhesive sustained-release tablets and non-bioadhesive tablets in adhering with gastric mucosa and small intestines mucosa(P
