Effects of Wen-Jin-Tong on the formation of advanced glycation end products and expressions of RAGE and ICAM-1 in cardiovascular tissues of diabetic rats
- VernacularTitle:温筋通对糖尿病大鼠心血管组织糖基化终产物的形成及其受体和ICAM-1表达的影响
- Author:
Jianwei ZHANG
;
Renyu SUN
;
Daiyi TANG
;
Xiaochu LIANG
- Publication Type:Journal Article
- Keywords:
Endothelium;
Cells;
Glycosylation end products, advanced;
Cell adhesion molecules
- From:Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of a Chinese herb compound prescription, Wen-Jin-Tong(WJT), on the deposition of advanced glycation end products (AGEs) ,the expression of receptor for AGEs(RAGE)and ICAM-1 in cardiovascular tissues of diabetic rats. METHODS: The diabetic rat model was induced by injection of streptozotocin. The quantity of AGEs accumulation, the expressions of RAGE and ICAM-1 in aorta and cardiac tissues were detected using fluorescence method, RT-PCR and in situ hybridization techniques. RESULTS: AGEs accumulation in aorta and cardiac tissues of rats treated with Wen-Jin-Tong was lower than that of diabetic model rats(P
