The renal protective effects of angiotensinⅡ typeⅠreceptor antagonist and angiotensin-converting enzyme inhibitor and their influences on intrarenal renin-angiotensin system
- VernacularTitle:血管紧张素ⅡⅠ型受体拮抗剂和血管紧张素转换酶抑制剂的肾保护作用及其对肾内肾素-血管紧张素系统的影响
- Author:
Anyu ZHOU
;
Ling YU
;
Jingzi LI
;
Junfeng ZHANG
;
Haiya WANG
- Publication Type:Journal Article
- Keywords:
Renin-angiotensin-system;
Nephrotic sydrome;
Angiotensin Ⅱ;
Angiotensin-converting enzyme inhibitors
- From:Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To compare the renoprotective effects of angiotensinⅡtypeⅠreceptor antagonist (AT 1RA) with that of angiotensin converting enzyme inhibitor (ACEI) and to investigate their influences on intrarenal renin-angiotensin system. METHODS: Experimental nephrotic syndrome model was induced in SD rats with repeated peritoneal injections of puromycin. Twenty-eight rats were randomly divided into four groups: normal control, nephrotic control, ACEI-treated and AT 1RA-treated group. Serum, urine and renal tissue were collected for study 12 weeks later. RESULTS: The urine protein was less and renal function was better in both treated groups. The glomerular and interstitial injury indexes of both ACEI and AT 1RA treated rats were lower than that of nephrotic control rats and had no significant difference between the two treated groups. The renal local ACE activity and angiotensinⅡ of nephrotic control group were significantly higher than that of normal control group and the two treated group(P
