Effects of Tripterygium wilfordii on the Production and Activities of IL－ 1 and IL－ 2 in vitro
- VernacularTitle:体外雷公藤内酯醇对白介素1和白介素2生成和活性的抑制
- Author:
Xinyu LI
;
Jiarun ZHENG
;
Meiyu TANG
- Publication Type:Journal Article
- Keywords:
Interleukin－ 1 Interleukin－ 2 Triptolide Cyclosporine
- From:
Chinese Journal of Dermatology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of the compound T0 extracted from Tripterygium wilfordii, a traditional Chinese herb, in comparison with those of cyclosporin A(CyA), on down－ regulating the expression and activities of IL－ 1 and IL－ 2. Methods The cellular reactive systems of peritoneal macrophage (rat)－ thymocytes (rat), and spleen cells (rat)－ CTLL－ 2 (mouse) were set up. The technique of 3H－ TdR incorporation was applied. Results The production of IL－ 1 and IL－ 2 were significantly inhibited by T0 and CyA. The activities of IL－ 1 and IL－ 2 were down－ regulated by T0,rather than by CyA. Conclusion T0 and CyA are potent inhibitors of the production of IL－ 1 and IL－ 2. Effects of T0 on the activities of IL－ 1 and IL－ 2 are different from those of CyA.
