Effect of hyperglycemia on the expressive type transformation of vascular smooth muscle cell in rats
- VernacularTitle:高血糖症对大鼠血管平滑肌细胞表型转变的影响
- Author:
Wenzhuo DUAN
;
Jiafu WANG
;
Yi DING
;
Tongmei LIU
;
Xiuyuan SONG
;
Jianying WANG
;
Haimin GONG
;
Chaoshu TANG
;
Xia LI
- Publication Type:Journal Article
- Keywords:
Hyperglycemia;
Muscle, smooth, vascular;
Phenotype;
Nitric oxide;
Endothelins
- From:Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To make hyperglycemia models and observe the effects of hyperglycemia on expressive type transformation of vascular smooth muscle cell (VSMC) in rats METHODS: Using tissue culture and radioactivity analysis methods RESULTS:①Hyperglycemia group was lower than control group in NO - 2 content, nitric oxide synthase activity and cGMP content;②Hyperglycemia group was higher than control group in endothelin, insulin, total chdesterol and [ 3H]-TdR penetrated rate of VSMC CONCLUSION: It was possible that hyperglycemia reduces the expressive type of VSMC to change and promotes VSMC proliferation
